Recent Publications
2026
Xu H, Jiang W, Xu L, Li H, Yang X, Zhu F, He P, Song Y, Li Y, Huang YA*, Qiu W*, Tang C*. "Astrocyte-intrinsic signaling of chitinase-like protein CHI3L1 drives inflammation and amplifies demyelination in neuromyelitis optica." Journal of Clinical Investigation, vol. 136, no. 1, 2026. (* Correspondence) Full Text PubMed
Yang X, Zhang X, Xu, Huang YA. "Neuronal UBE3A loss engages a TNF-driven neuron-to-microglia axis that promotes synapse remodeling." 2026. Full Text
Yang X, Huang, YA. "Stage-specific CHI3L1/YKL-40 signaling controls generation of oligodendrocyte precursor cells through IL13Rα2-mediated ferroptosis." 2026. Full Text
Yang X, Mayoral S, Jiang YH, Marshall J, Huang YA. "Targeting UBE3A and downstream estrogen receptor-β signaling to restore oligodendroglial homeostasis in Angelman syndrome." 2026. Full Text
Yang X, Jiang W, Li Y, Lee CG, Elias JA, Tang C, Huang YA. "CHI3L1/YKL-40 signaling inhibits neurogenesis in models of Alzheimer's disease." Science Advances, vol. 11, no. 29, 2025, pp. eadv1492. Full TextPubMed
Duckhorn J, Kim DK, Huang YA. "Bridging autophagy and endolysosomal dysfunction: Role of bridging integrator 1 in Alzheimer's disease." Neural regeneration research, 2025. Full TextPubMed
Palmer JE, Puri C, O'Rourke RS, Son SM, Sang C, Huang YA, Rubinsztein DC. "Coordination of autophagosome closure and release by the Alzheimer's disease-associated protein BIN1." Cell Reports, vol. 44, no. 9, 2025, pp. 116266. Full TextPubMed
Huie EZ, Yang X, Rioult-Pedotti MS, Tran K, Monsen ER, Hansen K, Erickson MA, Naik M, Yotova AY, Banks WA, Huang YA, Silverman JL, Marshall J. "Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model." Neuropsychopharmacology, vol. 50, no. 5, 2025, pp. 772-782. Full TextPubMed
Yang X, Huang YA*, Marshall J*. "UBE3A stabilization of β-catenin preserves synaptic proteins essential for motor and cognitive functions in Angelman Syndrome." Molecular autism, vol. 16, no. 1, 2025, pp. 60. (* Correspondence) Full TextPubMed
Yang X, Huang YA. "Unraveling the Roles of UBE3A in Neurodevelopment and Neurodegeneration." International Journal of Molecular Sciences, vol. 26, no. 5, 2025. Full TextPubMed
2024
Kloske CM, Mahinrad S, Barnum CJ, Batista AF, Bradshaw EM, Butts B, Carrillo MC, Chakrabarty P, Chen X, Craft S, Da Mesquita S, Dabin LC, Devanand D, Duran-Laforet V, Elyaman W, Evans EE, Fitzgerald-Bocarsly P, Foley KE, Harms AS, Heneka MT, Hong S, Huang YA, Jackvony S, Lai L, Guen YL, Lemere CA, Liddelow SA, Martin-Peña A, Orr AG, Quintana FJ, Ramey GD, Rexach JE, Rizzo SJS, Sexton C, Tang AS, Torrellas JG, Tsai AP, van Olst L, Walker KA, Wharton W, Tansey MG, Wilcock DM. "Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference." Alzheimer's & Dementia, 2024. Full TextPubMed
Song Y, Jiang W, Afridi SK, Wang T, Zhu F, Xu H, Nazir FH, Liu C, Wang Y, Long Y, Huang YA, Qiu W, Tang C. "Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus." Cell Reports, vol. 43, no. 5, 2024, pp. 114226. Full TextPubMed
Xu, H., Jiang, W., Li, X., Jiang, J., Afridi, S.K., Deng, L., Li, R., Luo, E., Zhang, Z., Huang, Y.A., Cui, Y., So, K.-F., Chen, H., Qiu, W., Tang, C. "hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model." npj Regenerative Medicine, vol. 9, no. 1, 2024. Full Text
Yang X, Duckhorn J, Marshall J, Huang YA. "Interlinked destinies: How ubiquitin-proteasome and autophagy systems underpin neurocognitive outcomes." Experimental Neurology, vol. 379, 2024, pp. 114869. Full TextPubMed
Peng CS, Zhang Y, Liu Q, Marti GE, Huang YA, Südhof TC, Cui B, Chu S. "Nanometer-resolution tracking of single cargo reveals dynein motor mechanisms." Nature Chemical Biology, 2024. Full TextPubMed
Yang, X., Huang, Y.A., Marshall, J. "Targeting TrkB-PSD-95 coupling to mitigate neurological disorders." Neural Regeneration Research, 2024. Full Text
2023
Lau KA, Yang X, Rioult-Pedotti MS, Tang S, Jianan Zhang MA, Tian Y, Marino C, Yao M, Jiang Q, Tsuda AC, Huang YA, Cao C, Marshall J. "A PSD-95 peptidomimetic mitigates neurological deficits in a mouse model of Angelman Syndrome." Progress in neurobiology, 2023, pp. 102513. Full TextPubMed
O'Rourke R, Erdemir GA, Huang YA. "Assays of Monitoring and Measuring Autophagic Flux for iPSC-Derived Human Neurons and Other Brain Cell Types." Methods in Molecular Biology, vol. 2683, 2023, pp. 221-233. Full TextPubMed
Jiang W, Zhu F, Xu H, Xu L, Li H, Yang X, Khan Afridi S, Lai S, Qiu X, Liu C, Li H, Long Y, Wang Y, Connolly K, Elias JA, Lee CG, Cui Y, Huang YA*, Qiu W*, Tang C*. "CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation." Science Advances, vol. 9, no. 39, 2023, pp. eadg8148. (* Correspondence) Full TextPubMed
Xu L, Xu H, Chen S, Jiang W, Afridi SK, Wang Y, Ren X, Zhao Y, Lai S, Qiu X, Huang YA, Cui Y, Yang H, Qiu W, Tang C. "Inhibition of complement C3 signaling ameliorates locomotor and visual dysfunction in autoimmune inflammatory diseases." Molecular therapy : the journal of the American Society of Gene Therapy, 2023. Full TextPubMed
Connolly K, Lehoux M, Assetta B, Huang YA. "Modeling Cellular Crosstalk of Neuroinflammation Axis by Tri-cultures of iPSC-Derived Human Microglia, Astrocytes, and Neurons." Methods in Molecular Biology, vol. 2683, 2023, pp. 79-87. Full TextPubMed
Walek KW, Stefan S, Lee JH, Puttigampala P, Kim AH, Park SW, Marchand PJ, Lesage F, Liu T, Huang YA, Boas DA, Moore C, Lee J. "Near-lifespan longitudinal tracking of brain microvascular morphology, topology, and flow in male mice." Nature Communications, vol. 14, no. 1, 2023, pp. 2982. Full TextPubMed
Lehoux M, Connolly K, Assetta B, Huang YA. "The Generation and Functional Characterization of Human Microglia-Like Cells Derived from iPS and Embryonic Stem Cells." Methods in Molecular Biology, vol. 2683, 2023, pp. 69-78. Full TextPubMed
2020-2022
Connolly K, Lehoux M, O'Rourke R, Assetta B, Erdemir GA, Elias JA, Lee CG, Huang YA. "Potential role of chitinase-3-like protein 1 (CHI3L1/YKL-40) in neurodegeneration and Alzheimer's disease." Alzheimer's & Dementia, vol. 19, no. 1, 2022, pp. 9-24. Full TextPubMed
Pak, ChangHui, Danko, Tamas, Mirabella, Vincent R., Wang, Jinzhao, Liu, Yingfei, Vangipuram, Madhuri, Grieder, Sarah, Zhang, Xianglong, Ward, Thomas, Huang, Yu-Wen Alvin, Jin, Kang, Dexheimer, Philip, Bardes, Eric, Mitelpunkt, Alexis, Ma, Junyi, McLachlan, Michael, Moore, Jennifer C., Qu, Pingping, Purmann, Carolin, Dage, Jeffrey L., Swanson, Bradley J., Urban, Alexander E., Aronow, Bruce J., Pang, Zhiping P., Levinson, Douglas F., Wernig, Marius, Südhof, Thomas C. "Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived NRXN1-mutant neurons." Proceedings of the National Academy of Sciences, 2021, pp. e2025598118. Full TextPubMed
Benedetta Assetta, Changyong Tang, Jing Bian, Ryan O'Rourke, Kevin Connolly, Thomas Brickler, Sundari Chetty, Yu-Wen Alvin Huang. "Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions." Journal of visualized experiments : JoVE, 2020. Full TextPubMed
~2019 (Selected)
Huang, Yu-Wen Alvin*, Zhou, Bo, Nabet, Amber M., Wernig, Marius, Südhof, Thomas C*. "Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk." The Journal of Neuroscience, 2019, pp. 2994-18. (* Correspondence) Full TextPubMed
Essayan-Perez, Sofia, Zhou, Bo, Nabet, Amber M., Wernig, Marius, Huang, Yu-Wen Alvin. "Modeling Alzheimer’s disease with human iPS cells: advancements, lessons, and applications." Neurobiology of Disease, vol. 130, 2019, pp. 104503. Full TextPubMed
Huang, Yu-Wen Alvin, Zhou, Bo, Wernig, Marius, Südhof, Thomas C. "ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion." Cell, vol. 168, no. 3, 2017, pp. 427-441.e21. Full TextPubMed
Huang, Yu-Wen A., Ruiz, Claudia R., Eyler, Elizabeth C.H., Lin, Kathie, Meffert, Mollie K. "Dual Regulation of miRNA Biogenesis Generates Target Specificity in Neurotrophin-Induced Protein Synthesis." Cell, vol. 148, no. 5, 2012, pp. 933-946. Full TextPubMed
Tang, Sung-Chun, Huang, Yu-Wen, Shieh, Jiann-Shing, Huang, Sheng-Jean, Yip, Ping-Keung, Jeng, Jiann-Shing. "Dynamic cerebral autoregulation in carotid stenosis before and after carotid stenting." Journal of Vascular Surgery, vol. 48, no. 1, 2008, pp. 88-92. Full TextPubMed
Tsai, Chung-Fen, Wu, Ruey-Meei, Huang, Yu-Wen, Chen, Li-Ling, Yip, Ping-Keung, Jeng, Jiann-Shing. "Transcranial color-coded sonography helps differentiation between idiopathic Parkinson's disease and vascular parkinsonism." Journal of Neurology, vol. 254, no. 4, 2007, pp. 501-507. Full TextPubMed
Huang, Yu-Wen, Jeng, Jiann-Shing, Tsai, Chung-Fen, Chen, Li-Ling, Wu, Ruey-Meei. "Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease." Movement Disorders, vol. 22, no. 4, 2007, pp. 550-555. Full TextPubMed