Recent Publications

2025

Yang X, Jiang W, Li Y, Lee CG, Elias JA, Tang C, Huang YA. "CHI3L1/YKL-40 signaling inhibits neurogenesis in models of Alzheimer's disease." Science Advances, vol. 11, no. 29, 2025, pp. eadv1492. Full Text PubMed

Duckhorn J, Kim DK, Huang YA. "Bridging autophagy and endolysosomal dysfunction: Role of bridging integrator 1 in Alzheimer's disease." Neural regeneration research, 2025. Full Text PubMed

Palmer JE, Puri C, O'Rourke RS, Son SM, Sang C, Huang YA, Rubinsztein DC. "Coordination of autophagosome closure and release by the Alzheimer's disease-associated protein BIN1." Cell Reports, vol. 44, no. 9, 2025, pp. 116266. Full Text PubMed

Huie EZ, Yang X, Rioult-Pedotti MS, Tran K, Monsen ER, Hansen K, Erickson MA, Naik M, Yotova AY, Banks WA, Huang YA, Silverman JL, Marshall J. "Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model." Neuropsychopharmacology, vol. 50, no. 5, 2025, pp. 772-782. Full Text PubMed

Yang X, Huang YA*, Marshall J*. "UBE3A stabilization of β-catenin preserves synaptic proteins essential for motor and cognitive functions in Angelman Syndrome." Molecular autism, vol. 16, no. 1, 2025, pp. 60. (* Correspondence) Full Text PubMed

Yang X, Huang YA. "Unraveling the Roles of UBE3A in Neurodevelopment and Neurodegeneration." International Journal of Molecular Sciences, vol. 26, no. 5, 2025. Full Text PubMed

2024

Kloske CM, Mahinrad S, Barnum CJ, Batista AF, Bradshaw EM, Butts B, Carrillo MC, Chakrabarty P, Chen X, Craft S, Da Mesquita S, Dabin LC, Devanand D, Duran-Laforet V, Elyaman W, Evans EE, Fitzgerald-Bocarsly P, Foley KE, Harms AS, Heneka MT, Hong S, Huang YA, Jackvony S, Lai L, Guen YL, Lemere CA, Liddelow SA, Martin-Peña A, Orr AG, Quintana FJ, Ramey GD, Rexach JE, Rizzo SJS, Sexton C, Tang AS, Torrellas JG, Tsai AP, van Olst L, Walker KA, Wharton W, Tansey MG, Wilcock DM. "Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference." Alzheimer's & Dementia, 2024. Full Text PubMed

Song Y, Jiang W, Afridi SK, Wang T, Zhu F, Xu H, Nazir FH, Liu C, Wang Y, Long Y, Huang YA, Qiu W, Tang C. "Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus." Cell Reports, vol. 43, no. 5, 2024, pp. 114226. Full Text PubMed

Xu, H., Jiang, W., Li, X., Jiang, J., Afridi, S.K., Deng, L., Li, R., Luo, E., Zhang, Z., Huang, Y.A., Cui, Y., So, K.-F., Chen, H., Qiu, W., Tang, C. "hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model." npj Regenerative Medicine, vol. 9, no. 1, 2024. Full Text

Yang X, Duckhorn J, Marshall J, Huang YA. "Interlinked destinies: How ubiquitin-proteasome and autophagy systems underpin neurocognitive outcomes." Experimental Neurology, vol. 379, 2024, pp. 114869. Full Text PubMed

Peng CS, Zhang Y, Liu Q, Marti GE, Huang YA, Südhof TC, Cui B, Chu S. "Nanometer-resolution tracking of single cargo reveals dynein motor mechanisms." Nature Chemical Biology, 2024. Full Text PubMed

Yang, X., Huang, Y.A., Marshall, J. "Targeting TrkB-PSD-95 coupling to mitigate neurological disorders." Neural Regeneration Research, 2024. Full Text

2023

Lau KA, Yang X, Rioult-Pedotti MS, Tang S, Jianan Zhang MA, Tian Y, Marino C, Yao M, Jiang Q, Tsuda AC, Huang YA, Cao C, Marshall J. "A PSD-95 peptidomimetic mitigates neurological deficits in a mouse model of Angelman Syndrome." Progress in neurobiology, 2023, pp. 102513. Full Text PubMed

O'Rourke R, Erdemir GA, Huang YA. "Assays of Monitoring and Measuring Autophagic Flux for iPSC-Derived Human Neurons and Other Brain Cell Types." Methods in Molecular Biology, vol. 2683, 2023, pp. 221-233. Full Text PubMed

Jiang W, Zhu F, Xu H, Xu L, Li H, Yang X, Khan Afridi S, Lai S, Qiu X, Liu C, Li H, Long Y, Wang Y, Connolly K, Elias JA, Lee CG, Cui Y, Huang YA*, Qiu W*, Tang C*. "CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation." Science Advances, vol. 9, no. 39, 2023, pp. eadg8148. (* Correspondence) Full Text PubMed

Xu L, Xu H, Chen S, Jiang W, Afridi SK, Wang Y, Ren X, Zhao Y, Lai S, Qiu X, Huang YA, Cui Y, Yang H, Qiu W, Tang C. "Inhibition of complement C3 signaling ameliorates locomotor and visual dysfunction in autoimmune inflammatory diseases." Molecular therapy : the journal of the American Society of Gene Therapy, 2023. Full Text PubMed

Connolly K, Lehoux M, Assetta B, Huang YA. "Modeling Cellular Crosstalk of Neuroinflammation Axis by Tri-cultures of iPSC-Derived Human Microglia, Astrocytes, and Neurons." Methods in Molecular Biology, vol. 2683, 2023, pp. 79-87. Full Text PubMed

Walek KW, Stefan S, Lee JH, Puttigampala P, Kim AH, Park SW, Marchand PJ, Lesage F, Liu T, Huang YA, Boas DA, Moore C, Lee J. "Near-lifespan longitudinal tracking of brain microvascular morphology, topology, and flow in male mice." Nature Communications, vol. 14, no. 1, 2023, pp. 2982. Full Text PubMed

Lehoux M, Connolly K, Assetta B, Huang YA. "The Generation and Functional Characterization of Human Microglia-Like Cells Derived from iPS and Embryonic Stem Cells." Methods in Molecular Biology, vol. 2683, 2023, pp. 69-78. Full Text PubMed

2020-2022

Connolly K, Lehoux M, O'Rourke R, Assetta B, Erdemir GA, Elias JA, Lee CG, Huang YA. "Potential role of chitinase-3-like protein 1 (CHI3L1/YKL-40) in neurodegeneration and Alzheimer's disease." Alzheimer's & Dementia, vol. 19, no. 1, 2022, pp. 9-24. Full Text PubMed

Pak, ChangHui, Danko, Tamas, Mirabella, Vincent R., Wang, Jinzhao, Liu, Yingfei, Vangipuram, Madhuri, Grieder, Sarah, Zhang, Xianglong, Ward, Thomas, Huang, Yu-Wen Alvin, Jin, Kang, Dexheimer, Philip, Bardes, Eric, Mitelpunkt, Alexis, Ma, Junyi, McLachlan, Michael, Moore, Jennifer C., Qu, Pingping, Purmann, Carolin, Dage, Jeffrey L., Swanson, Bradley J., Urban, Alexander E., Aronow, Bruce J., Pang, Zhiping P., Levinson, Douglas F., Wernig, Marius, Südhof, Thomas C. "Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived NRXN1-mutant neurons." Proceedings of the National Academy of Sciences, 2021, pp. e2025598118. Full Text PubMed

Benedetta Assetta, Changyong Tang, Jing Bian, Ryan O'Rourke, Kevin Connolly, Thomas Brickler, Sundari Chetty, Yu-Wen Alvin Huang. "Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions." Journal of visualized experiments : JoVE, 2020. Full Text PubMed

~2019 (Selected)

Huang, Yu-Wen Alvin*, Zhou, Bo, Nabet, Amber M., Wernig, Marius, Südhof, Thomas C*. "Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk." The Journal of Neuroscience, 2019, pp. 2994-18. (* Correspondence) Full Text PubMed

Essayan-Perez, Sofia, Zhou, Bo, Nabet, Amber M., Wernig, Marius, Huang, Yu-Wen Alvin. "Modeling Alzheimer’s disease with human iPS cells: advancements, lessons, and applications." Neurobiology of Disease, vol. 130, 2019, pp. 104503. Full Text PubMed

Huang, Yu-Wen Alvin, Zhou, Bo, Wernig, Marius, Südhof, Thomas C. "ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion." Cell, vol. 168, no. 3, 2017, pp. 427-441.e21. Full Text PubMed

Huang, Yu-Wen A., Ruiz, Claudia R., Eyler, Elizabeth C.H., Lin, Kathie, Meffert, Mollie K. "Dual Regulation of miRNA Biogenesis Generates Target Specificity in Neurotrophin-Induced Protein Synthesis." Cell, vol. 148, no. 5, 2012, pp. 933-946. Full Text PubMed

Tang, Sung-Chun, Huang, Yu-Wen, Shieh, Jiann-Shing, Huang, Sheng-Jean, Yip, Ping-Keung, Jeng, Jiann-Shing. "Dynamic cerebral autoregulation in carotid stenosis before and after carotid stenting." Journal of Vascular Surgery, vol. 48, no. 1, 2008, pp. 88-92. Full Text PubMed

Tsai, Chung-Fen, Wu, Ruey-Meei, Huang, Yu-Wen, Chen, Li-Ling, Yip, Ping-Keung, Jeng, Jiann-Shing. "Transcranial color-coded sonography helps differentiation between idiopathic Parkinson's disease and vascular parkinsonism." Journal of Neurology, vol. 254, no. 4, 2007, pp. 501-507. Full Text PubMed

Huang, Yu-Wen, Jeng, Jiann-Shing, Tsai, Chung-Fen, Chen, Li-Ling, Wu, Ruey-Meei. "Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease." Movement Disorders, vol. 22, no. 4, 2007, pp. 550-555. Full Text PubMed